Site-Selective Protein Immobilization by Staudinger Ligation

A sticky situation: A site‐specific immobilization of proteins onto a glass surface may allow the creation of protein microarrays. This approach relies on the Staudinger ligation between azide‐modified proteins and a phosphane‐functionalized glass surface.

Saved in:
Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 45; no. 9; pp. 1408 - 1412
Main Authors Watzke, Anja, Köhn, Maja, Gutierrez-Rodriguez, Marta, Wacker, Ron, Schröder, Hendrik, Breinbauer, Rolf, Kuhlmann, Jürgen, Alexandrov, Kirill, Niemeyer, Christof M., Goody, Roger S., Waldmann, Herbert
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 20.02.2006
WILEY‐VCH Verlag
Wiley
Subjects
Azides - chemical synthesis
Azides - chemistry
Binding Sites
bioorganic chemistry
Chemistry
Chemistry, Multidisciplinary
Glass - chemistry
Ligands
Molecular Conformation
Physical Sciences
protein microarrays
protein modification
Proteins - chemistry
Science & Technology
solid-phase synthesis
Staudinger ligation
Stereoisomerism
Surface Properties
CELL-SURFACES
bioorganic chemistry
Staudinger ligation
protein modification
MICROARRAYS
protein microarrays
solid-phase synthesis
Online AccessGet full text

Cover

More Information
Summary:A sticky situation: A site‐specific immobilization of proteins onto a glass surface may allow the creation of protein microarrays. This approach relies on the Staudinger ligation between azide‐modified proteins and a phosphane‐functionalized glass surface.
Bibliography:istex:04EDDEC9A28FF90F12085EA319D95AD4E379116A
This research was supported by the Volkswagen Stiftung, the Max Planck Gesellschaft, and the Fonds der Chemischen Industrie.
ArticleID:ANIE200502057
ark:/67375/WNG-775FXLCL-M
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502057