Integrated Microfluidics for Parallel Screening of an In Situ Click Chemistry Library

State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in situ click chemistry reactions with reduced consumption of reagents. A proof‐of‐concept study was performed with the bovine carbonic anhydra...

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Published inAngewandte Chemie International Edition Vol. 45; no. 32; pp. 5276 - 5281
Main Authors Wang, Jinyi, Sui, Guodong, Mocharla, Vani P., Lin, Rachel J., Phelps, Michael E., Kolb, Hartmuth C., Tseng, Hsian-Rong
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 11.08.2006
WILEY‐VCH Verlag
Wiley
Subjects
Chemistry
Chemistry, Multidisciplinary
click chemistry
Combinatorial Chemistry Techniques - instrumentation
Combinatorial Chemistry Techniques - methods
enzyme catalysis
high-throughput screening
Ligands
Microfluidics - instrumentation
microreactors
Molecular Structure
parallel synthesis
Physical Sciences
Proteins - chemistry
Science & Technology
ORGANIC-SYNTHESIS
microreactors
high-throughput screening
COMBINATORIAL LIBRARIES
click chemistry
enzyme catalysis
OPTIMIZATION
INHIBITORS
DISCOVERY
parallel synthesis
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Summary:State‐of‐the‐art: Automated chemical reaction circuits have been demonstrated to serve as a miniaturized operation platform for the parallel screening of 32 in situ click chemistry reactions with reduced consumption of reagents. A proof‐of‐concept study was performed with the bovine carbonic anhydrase II (bCAII) click chemistry system.
Bibliography:ark:/67375/WNG-89B0G2D7-B
istex:E557046280766605099B9457A5E61306C5328567
ArticleID:ANIE200601677
This research was supported by the NIH NanoSystems Biology Cancer Center, the DOE-UCLA Institute of Molecular Medicine, the NIH-UCLA Center for In Vivo Imaging in Cancer Biology, and Siemens Medical Solutions USA, Inc. G.S. thanks the UCLA SOMI program for a postdoctoral fellowship. We thank David Twomey for the artwork for the frontispiece.
This research was supported by the NIH NanoSystems Biology Cancer Center, the DOE‐UCLA Institute of Molecular Medicine, the NIH‐UCLA Center for In Vivo Imaging in Cancer Biology, and Siemens Medical Solutions USA, Inc. G.S. thanks the UCLA SOMI program for a postdoctoral fellowship. We thank David Twomey for the artwork for the frontispiece.
These authors contributed equally to the work.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601677