Risk of peptic ulcer, oesophagitis, pancreatitis or gallstone in patients with unexplained chest/epigastric pain and normal upper endoscopy: a 10‐year Danish cohort study

• Published in: Alimentary pharmacology & therapeutics Vol. 25; no. 10; pp. 1203 - 1210
• Main Authors: MUNK, E. M., DREWES, A. M., GORST‐RASMUSSEN, A., GREGERSEN, H., FUNCH‐JENSEN, P., NØRGÅRD, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 15.05.2007; Blackwell
• Subjects: Adult; Biological and medical sciences; Chest Pain - etiology; Cohort Studies; Digestive system; Endoscopy, Digestive System - methods; Esophagitis - complications; Esophagitis - diagnosis; Esophagus; Female; Gallstones - complications; Gallstones - diagnosis; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Pancreatitis - complications; Pancreatitis - diagnosis; Peptic Ulcer - complications; Peptic Ulcer - diagnosis; Pharmacology. Drug treatments; Risk Factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Denmark; Europe; Human; Esophagogastroduodenoscopy; Digestive system; Esophageal disease; Pancreatitis; Esophagitis; Peptic ulcer; Biliary tract disease; Epidemiology; Cholelithiasis; Gastroduodenal; chest pain; Cohort study; Risk factor; Digestive diseases; Intestinal disease; Gallbladder; Public health; Gastric disease; Pancreatic disease
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2007.03315.x

SUMMARY Background  No studies have examined the risk of upper gastrointestinal diseases among patients with unexplained chest/epigastric pain (UCEP) and a normal upper endoscopy. Aim  To examine the relative risk of peptic ulcer, oesophagitis, pancreatitis or gallstone in UCEP patients. Methods  This Danish 10‐year cohort study focused on UCEP patients (n = 386), diagnosed in 1992–93. Ten age‐ and gender‐matched controls were selected per patient from Denmark’s Civil Registration System (n = 3860). Kaplan–Meier analysis and Cox’s regression analysis was used to calculate the risk of hospitalization for peptic ulcer, oesophagitis, pancreatitis or gallstone. Results  Compared with controls, the adjusted relative risks among UCEP patients <1 and ≥1 year after upper endoscopy were for peptic ulcer 2.0 [95% confidence interval (CI) 0.2–18.4] and 1.7 (95% CI 0.9–3.4), for oesophagitis 8.2 (95% CI 1.2–59.2) and 1.9 (95% CI 0.7–5.0), for pancreatitis 9.2 (95% CI 2.0–41.8) and 3.9 (95% CI 1.4–10.5), and for gallstone 14.1 (95% CI 5.4–37.2) and 3.3 (95% CI 1.9–5.8). Conclusions  UCEP is positively associated with all study outcomes especially in the first year after upper endoscopy, indicating that peptic ulcer, oesophagitis, pancreatitis or gallstone could be underlying early UCEP symptoms. However, the long‐term association remained strong for pancreatitis and gallstone, suggesting a genuine excess risk.