Serum lactate dehydrogenase activity as a biomarker in children with sickle cell disease

• Published in: British journal of haematology Vol. 140; no. 2; pp. 206 - 209
• Main Authors: O’Driscoll, Sandra, Height, Susan E., Dick, Moira C., Rees, David C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2008; Blackwell
• Subjects: Adolescent; Anemia, Sickle Cell - diagnosis; Anemia, Sickle Cell - diagnostic imaging; Anemia, Sickle Cell - physiopathology; Anemias. Hemoglobinopathies; Biological and medical sciences; Biomarkers - blood; Cerebrovascular Circulation; Child; Child, Preschool; Clinical Enzyme Tests - methods; Diseases of red blood cells; Female; haemolysis; Hematologic and hematopoietic diseases; Hemoglobin SC Disease - diagnosis; Hemoglobin SC Disease - diagnostic imaging; Hemoglobin SC Disease - physiopathology; Hospitalization; Humans; L-Lactate Dehydrogenase - blood; lactate dehydrogenase; Male; Medical sciences; paediatric; sickle cell disease; transcranial Doppler; Ultrasonography, Doppler, Transcranial; Sonography; Human; Doppler ultrasound study; Hemolysis; Hemoglobinopathy; Sickle cell anemia; Hematology; Enzyme; Biological marker; lactate dehydrogenase; Hemopathy; Biological activity; L-Lactate dehydrogenase; Genetic disease; paediatric; sickle cell disease; Transcranial route; Hemolytic anemia; transcranial Doppler; haemolysis; Serum; Oxidoreductases; Child
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.2007.06894.x

Summary Serum lactate dehydrogenase (LDH) levels were studied in children with HbSS and HbSC in a single institution, and their relationship to cerebral vasculopathy as assessed by transcranial Doppler scanning (TCD). All children with HbSS (n = 97) and HbSC (n = 18) who underwent a TCD scan in 2006 were studied. LDH levels were higher in HbSS patients than HbSC (581 IU/l vs. 305 IU/l, P < 0·001). In children with HbSS, LDH correlated significantly with haemoglobin, reticulocytes, aspartate transaminase and creatinine. LDH also correlated positively and significantly with TCD measurements in the middle and anterior cerebral artery circulations in the children with HbSS.