Enantioselective Enzymatic Reactions in Miniemulsions as Efficient "Nanoreactors"

• Published in: Angewandte Chemie International Edition Vol. 45; no. 10; pp. 1645 - 1648
• Main Authors: Gröger, Harald, May, Oliver, Hüsken, Hendrik, Georgeon, Sandrine, Drauz, Karlheinz, Landfester, Katharina
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 27.02.2006; WILEY‐VCH Verlag; Wiley
• Subjects: Animals; biphasic catalysis; Chemistry; Chemistry, Multidisciplinary; emulsions; Emulsions - chemistry; enantioselectivity; enzyme catalysis; hydrolysis; Lipase - metabolism; Nanostructures - chemistry; Phenylalanine - chemistry; Phenylalanine - metabolism; Physical Sciences; Science & Technology; Solvents; Stereoisomerism; Substrate Specificity; Swine; enantioselectivity; LIPASES; emulsions; BIOORGANIC REACTIONS; MICROEMULSIONS; biphasic catalysis; RESOLUTION; enzyme catalysis; hydrolysis
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.200502854

Phasing in: Miniemulsions are homogenous mixtures in which the organic phase is dispersed in the form of nanometer‐scale droplets, which can act as efficient “nanoreactors” for enantioselective enzymatic transformations. Very high substrate concentrations are possible, and both α‐ and β‐amino acids were prepared with high conversions and up to >99 % ee.