Prenatal effects of Ochratoxin A in hamsters

Pregnant golden hamsters were injected ip with 2.5-20 mg/kg ochratoxin A on one of gestation days 7-10. The largest dosages when given on day 7,8, or 9 increased prenatal mortality and on day 9 diminished fetal growth. Malformations, such as micrognathia, hydrocephalus, short tail, oligodactyly, syn...

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Bibliographic Details
Published inTeratology (Philadelphia) Vol. 13; no. 1; p. 11
Main Authors Hood, R D, Naughton, M J, Hayes, A W
Format Journal Article
LanguageEnglish
Published United States 01.02.1976
Subjects
Abnormalities, Drug-Induced
Animals
Body Weight
Chick Embryo
Cricetinae
Dose-Response Relationship, Drug
Female
Male
Mice
Ochratoxins - administration & dosage
Ochratoxins - toxicity
Pregnancy
Species Specificity
Time Factors
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Summary:Pregnant golden hamsters were injected ip with 2.5-20 mg/kg ochratoxin A on one of gestation days 7-10. The largest dosages when given on day 7,8, or 9 increased prenatal mortality and on day 9 diminished fetal growth. Malformations, such as micrognathia, hydrocephalus, short tail, oligodactyly, syndactyly, cleft lip, micromelia, and heart defects occurred, but no skeletal malformations were noted. These results add to the prenatal effects of ochratoxin A previously reported in mouse, rat, and chicken embryos.
ISSN:0040-3709
DOI:10.1002/tera.1420130103