Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Converging on the goal: New chemistry enables the key Cys‐peptide‐(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligatio...

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Published inAngewandte Chemie International Edition Vol. 45; no. 24; pp. 3985 - 3988
Main Authors Bang, Duhee, Pentelute, Brad L., Kent, Stephen B. H.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 12.06.2006
WILEY‐VCH Verlag
Subjects
Kinetics
native chemical ligation
peptides
Peptides - chemistry
Plant Proteins - chemical synthesis
protein synthesis
Proteins - chemical synthesis
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Summary:Converging on the goal: New chemistry enables the key Cys‐peptide‐(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.
Bibliography:ArticleID:ANIE200600702
istex:557A99E867938D369FC910AB106795B0822CF54B
ark:/67375/WNG-S07PGP0N-7
This work was supported by funding from the DOE GTL program (grant DE-FG02-04ER63786 to S.B.K).
This work was supported by funding from the DOE GTL program (grant DE‐FG02‐04ER63786 to S.B.K).
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200600702