Transient global amnesia associated with a unilateral infarction of the fornix: case report and review of the literature

Stroke is an extremely uncommon cause of transient global amnesia (TGA). Unilateral lesions of the fornix rarely cause amnesia and have not previously been reported to be associated with the distinctive amnesic picture of TGA. We describe the case of a 60-year-old woman who presented with acute onse...

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Published inFrontiers in neurology Vol. 5; p. 291
Main Authors Gupta, Mihir, Kantor, Molly A, Tung, Christie E, Zhang, Niushen, Albers, Gregory W
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2014
Subjects
Amnesia, Transient Global
Brain Infarction
Fornix, Brain
MRI
Neuroscience
Stroke
transient global
amnesia
brain infarction
fornix
brain
stroke
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Summary:Stroke is an extremely uncommon cause of transient global amnesia (TGA). Unilateral lesions of the fornix rarely cause amnesia and have not previously been reported to be associated with the distinctive amnesic picture of TGA. We describe the case of a 60-year-old woman who presented with acute onset, recent retrograde, and anterograde amnesia characteristic of TGA. Serial magnetic resonance imaging showed a persistent focal infarction of the body and left column of the fornix, without acute lesions in the hippocampus or other structures. Amnesia resolved in 6 h. Infarction of the fornix should thus be included in the differential diagnosis of TGA, as it changes the management of this otherwise self-limited syndrome.
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Edited by: Laszlo Csiba, University of Debrecen, Hungary
Reviewed by: Edward C. Jauch, Medical University of South Carolina, USA; Velandai Srikanth, Monash University, Australia
This article was submitted to Stroke, a section of the journal Frontiers in Neurology.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2014.00291