Shared Heritability of Blood Pressure and Pulse Wave Velocity: Insights From the STANISLAS Cohort

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 80; no. 7; pp. 1526 - 1533
• Main Authors: Xhaard, Constance, de Villemereuil, Pierre, Benetos, Athanase, Bozec, Erwan, Dandine-Roulland, Claire, Le Floch, Edith, Regnault, Véronique, Lacolley, Patrick, Zannad, Faiez, Rossignol, Patrick, Girerd, Nicolas
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.07.2023; American Heart Association
• Subjects: Life Sciences; arterial stiffness; blood pressure; genetics; pulse wave velocity; genetic correlation; heritability
• ISSN: 0194-911X; 1524-4563; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.122.20740

Pulse wave velocity (PWV) is a marker of arterial stiffness, which is intrinsically highly correlated with blood pressure (BP). However, the interplay of PWV and BP heritability has not been extensively studied. This study aimed to estimate the heritability of PWV and BP and determine the genetic correlation between PWV and BP. The heritability of PWV and BP was estimated in 1080 subjects from the STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux) cohort with at least one relative using a linear mixed model within one frequentist and one Bayesian framework implemented, respectively, in the Gaston and MCMCglmm R packages. Then their genetic correlations were also estimated. The heritability estimations for PWV were within the same range of the heritability of systolic BP and diastolic BP (23%, 19%, and 27%, respectively). Daytime heritability of BP was higher than nighttime BP. In addition, phenotypic correlations between PWV and systolic BP/diastolic BP were, respectively, 0.34 and 0.23, whereas nonsignificant genetic correlations were 0.08 and 0.22 respectively, indicating that PWV and diastolic BP shared more polygenic codeterminants than PWV and systolic BP. Our results suggest that the heritability of PWV is >20% and within the same range as BP heritability. It also suggests that the link between PWV and BP goes beyond phenotypic association: PWV and BP (in particular diastolic BP) share common genetic determinants. This genetic interdependence of PWV and BP appears largely polygenic.