Trends in prostate cancer incidence among Black men in the Caribbean and the United States

• Published in: The Prostate Vol. 83; no. 12; pp. 1207 - 1216
• Main Authors: Zeigler‐Johnson, Charnita, McDonald, Alicia C., Pinheiro, Paulo, Lynch, Shannon, Taioli, Emanuela, Joshi, Shivam, Alpert, Naomi, Baudin, Jacqueline, Joachim, Clarisse, Deloumeaux, Jacqueline, Oliver, JoAnn, Bhakkan‐Mambir, Bernard, Beaubrun‐Renard, Murielle, Ortiz, Angel G., Ragin, Camille
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2023; Wiley
• Subjects: Black men; Black people; Cancer screening; Caribbean; Caribbean Region - epidemiology; Diaspora; Early Detection of Cancer; Humans; Incidence; incidence rates; Life Sciences; Male; Medical screening; Population studies; Prostate cancer; Prostate-Specific Antigen; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - pathology; Standardization; Trends; United States - epidemiology; United States; Caribbean Region; New York; Martinique; United States > US; Guadeloupe; prostate cancer; incidence rates; Caribbean; Black men
• ISSN: 0270-4137; 1097-0045; 1097-0045
• DOI: 10.1002/pros.24580

Background Prostate cancer incidence is highest for Black men of the African diaspora in the United States and Caribbean. Recent changes in recommendations for prostate cancer screening have been shown to decrease overall prostate cancer incidence and increase the likelihood of late stage disease. However, it is unclear how trends in prostate cancer characteristics among high risk Black men differ by geographic region during the changes in screening recommendations. Methods In this study, we used population‐based prostate cancer registry data to describe age‐adjusted prostate cancer incidence trends from 2008 to 2015 among Black men from six geographic regions. We obtained data on incident Black prostate cancer patients from six cancer registries (in the United States: Florida, Alabama, Pennsylvania, and New York; and in the Caribbean: Guadeloupe and Martinique). After age standardization, we used descriptive analyses to compare the demographics and tumor characteristics by cancer registry site. The Joinpoint regression program was used to compare the trends in incidence by site. Results A total of 59,246 men were analyzed. We found the highest incidence rates (per 100,000) for prostate cancer in the Caribbean countries (181.99 in Martinique and 176.62 in Guadeloupe) and New York state (178.74). Incidence trends decreased significantly over time at all sites except Martinique, which also showed significantly increasing rates of late stage (III/IV) and Gleason score 7+ tumors. Conclusions We observed significant differences in prostate cancer incidence trends among Black men after major changes prostate screening recommendations. Future studies will examine the factors that differentially influence prostate cancer trends among the African diaspora.