Highly Active, Entirely Biobased Antimicrobial Pickering Emulsions
We present the development of surfactant‐free, silica‐free and fully biobased oil‐in‐water antimicrobial Pickering emulsions, based on the self‐assembly of β‐cyclodextrin and phytoantimicrobial oils (terpinen‐4‐ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio‐base...
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Published in | ChemMedChem Vol. 16; no. 14; pp. 2223 - 2230 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Germany
Wiley Subscription Services, Inc
20.07.2021
Wiley-VCH Verlag |
Series | ChemMedChem |
Subjects | |
Online Access | Get full text |
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Summary: | We present the development of surfactant‐free, silica‐free and fully biobased oil‐in‐water antimicrobial Pickering emulsions, based on the self‐assembly of β‐cyclodextrin and phytoantimicrobial oils (terpinen‐4‐ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio‐based drug to treat fungal infection, but is less effective than petroleum‐based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram‐positive and Gram‐negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin‐resistant S. aureus (MRSA), compared to UA and azole‐based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans. Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental‐friendly emulsion.
Assembling awesome antibacterials! Surfactant‐free, silica‐free and fully biobased oil‐in‐water antimicrobial Pickering emulsions, based on the self‐assembly of phytochemical compounds (β‐cyclodextrin and carvacrol) can be used to maximize the antifungal potential of undecylenic acid against fungi and bacteria. These environmental‐friendly emulsions are up to +480 % more efficient that commercial ointment and present remarkable eradication of MRSA biofilms. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1860-7179 1860-7187 |
DOI: | 10.1002/cmdc.202100030 |