Distinguishing Structural and Functional Restraints in Evolution in Order to Identify Interaction Sites

• Published in: Journal of molecular biology Vol. 342; no. 5; pp. 1487 - 1504
• Main Authors: Chelliah, Vijayalakshmi, Chen, Lan, Blundell, Tom L., Lovell, Simon C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2004
• Subjects: Algorithms; Animals; Biological Evolution; Conserved Sequence; environment-specific substitution tables; evolution; functional sites; Humans; Models, Molecular; Molecular Structure; Protein Conformation; protein function; Protein Interaction Mapping; Proteins - chemistry; Sequence Alignment - statistics & numerical data; Software; MDH; functional sites; LDH; IGF; protein function; environment-specific substitution tables; RMSD; evolution; pdb

Structural genomics projects are producing many three-dimensional structures of proteins that have been identified only from their gene sequences. It is therefore important to develop computational methods that will predict sites involved in productive intermolecular interactions that might give clu...