Two new benzolactones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities

Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3-6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including exte...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 30; no. 13; pp. 1464 - 1469
Main Authors Shen, Qinpeng, Xu, Xingmeng, Zhang, Fengmei, Xiang, Nengjun, He, Pei, Si, Xiaoxi, Zhu, Ruizhi, Wang, Kunmiao, Liu, Zhihua, Liu, Chunbo, Miao, Mingming
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.07.2016
Subjects
anti-tobacco mosaic virus activities
Antiviral Agents - pharmacology
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
benzolactones
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Nicotiana - chemistry
Nicotiana tabacum
Plant Leaves - chemistry
Tobacco Mosaic Virus - drug effects
Nicotiana tabacum
benzolactones
anti-tobacco mosaic virus activities
Online AccessGet full text

Cover

More Information
Summary:Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3-6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1-6 exhibited high anti-TMV activities with inhibition rates in the range of 16.9-26.2%, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1104675