Anticonvulsant effects of ivermectin in genetically-epileptic chickens
In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was...
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| Published in | Neuropharmacology Vol. 25; no. 10; p. 1085 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.10.1986
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| Subjects | |
| Online Access | Get more information |
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| Abstract | In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam. |
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| AbstractList | In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam. |
| Author | Crichlow, E C Crawford, R D Mishra, P R |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3785577$$D View this record in MEDLINE/PubMed |
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| Snippet | In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by... |
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| SubjectTerms | Animals Anticonvulsants Chickens - physiology Diazepam - pharmacology Epilepsy - genetics Epilepsy - physiopathology Epilepsy - veterinary Ivermectin - pharmacology Mutation Photic Stimulation Poultry Diseases - genetics Poultry Diseases - physiopathology |
| Title | Anticonvulsant effects of ivermectin in genetically-epileptic chickens |
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