Anticonvulsant effects of ivermectin in genetically-epileptic chickens

In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was...

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Bibliographic Details
Published inNeuropharmacology Vol. 25; no. 10; p. 1085
Main Authors Crichlow, E C, Mishra, P R, Crawford, R D
Format Journal Article
LanguageEnglish
Published England 01.10.1986
Subjects
Animals
Anticonvulsants
Chickens - physiology
Diazepam - pharmacology
Epilepsy - genetics
Epilepsy - physiopathology
Epilepsy - veterinary
Ivermectin - pharmacology
Mutation
Photic Stimulation
Poultry Diseases - genetics
Poultry Diseases - physiopathology
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Summary:In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam.
ISSN:0028-3908
DOI:10.1016/0028-3908(86)90154-1