Interplay of mechanical deformation and patterned gene expression in developing embryos

The shaping of the early embryo requires pattern formation as well as geometric and topological morphogenesis of the developing tissues. The morphogenetic movements that lead to geometric shape changes are controlled by patterned gene expression. How particular movements are related to patterning ge...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 14; no. 4; pp. 367 - 374
Main Authors Brouzés, Eric, Farge, Emmanuel
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2004
Subjects
Animals
Body Patterning - physiology
Cell Movement - physiology
Drosophila - embryology
Embryonic Development - physiology
Gene Expression Regulation, Developmental
Models, Biological
Morphogenesis
BMP
MAPK
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Summary:The shaping of the early embryo requires pattern formation as well as geometric and topological morphogenesis of the developing tissues. The morphogenetic movements that lead to geometric shape changes are controlled by patterned gene expression. How particular movements are related to patterning genes, and which underlying molecular and cellular mechanisms lead to coordinated macroscopic movements that induce morphogenesis, remain the challenging questions of embryonic development. How morphogenetic movements could modulate the expression of developmental genes is an emerging question, potentially opening new horizons in developmental biology. This question instigates the task of characterizing the molecular and cellular mechanisms underlying these mechano-transcription events.
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ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2004.06.005