Contribution of bone turnover markers to bone mass in pubertal boys and girls

• Published in: Journal of Pediatric Endocrinology and Metabolism Vol. 24; no. 11-12; pp. 971 - 974
• Main Authors: Gracia-Marco, Luis, Ortega, Francisco B., Jiménez-Pavón, David, Rodríguez, Gerardo, Valtueña, Jara, Díaz-Marténez, Ángel E., González-Gross, Marcela, Castillo, Manuel J., Vicente-Rodríguez, Germán, Moreno, Luis A.
• Format: Journal Article
• Language: English
• Published: Germany Walter de Gruyter 2011
• Subjects: Absorptiometry, Photon; Adolescent; adolescents; Biomarkers - metabolism; Bone and Bones - diagnostic imaging; Bone and Bones - metabolism; Bone Density - physiology; bone health; Bone Remodeling - physiology; bone turnover; Child; dual energy X-ray absorptiometry; Female; Humans; Male; Medicin och hälsovetenskap; metabolism; Motor Activity - physiology; physical activity; Puberty - physiology
• ISSN: 0334-018X; 2191-0251
• DOI: 10.1515/JPEM.2011.326

Background and aims: The association between bone turnover markers and bone mass in adolescence is not clear. We aimed to evaluate the associations between bone turnover markers and bone mineral content (BMC), density (BMD) and area (BMA). Subjects: A total of 56 adolescents (25 boys, 12.5–17.5 years) participated in the study. Methods: Bone mass and physical activity (PA) were measured using dual energy X-ray absorptiometry and accelero­meters. Osteocalcin and amino-terminal propeptide of type I procollagen (PINP), as markers of bone formation, and β-isomer of the C-terminal telopeptide of type I collagen, as marker of bone resorption were also measured. Sexual maturation, weight, height and average PA were considered as confounders. Results: Positive correlations (Pearson) were observed among the three bone turnover markers (r=0.7–0.9). Stepwise multiple linear regression analyses showed that PINP was strong and negatively associated with BMC, BMD and BMA in girls, explaining 24.9% of the variance in BMC, 25.6% in BMD and 16.3% in BMA. Conclusion: PINP is a strong predictor of bone related variables in pubertal girls.