Hydrocephalus, cerebral vasospasm, and delayed cerebral ischemia following non-aneurysmatic spontaneous subarachnoid hemorrhages: an underestimated problem

• Published in: Neurosurgical review Vol. 46; no. 1; p. 23
• Main Authors: Wolfert, Christina, Maurer, Christoph J., Berlis, Ansgar, Schneider, Hauke, Steininger, Kathrin, Motov, Stefan, Krauss, Philipp, Sommer, Björn, Shiban, Ehab
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 22.12.2022
• Subjects: Brain Ischemia - complications; Cerebral Infarction - complications; Female; Humans; Hydrocephalus - complications; Hydrocephalus - surgery; Medicine; Medicine & Public Health; Middle Aged; Neurosurgery; Retrospective Studies; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - diagnosis; Subarachnoid Hemorrhage - surgery; Vasospasm, Intracranial - complications; Vasospasm, Intracranial - etiology; Cerebral vasospasm; Delayed cerebral ischemia; Occult subarachnoid hemorrhage; Negative angiography; Hydrocephalus; Outcome
• ISSN: 1437-2320; 0344-5607; 1437-2320
• DOI: 10.1007/s10143-022-01919-9

Non-aneurysmal subarachnoid hemorrhage (NASAH) is rare and mostly benign. However, complications such as cerebral vasospasm (CV), delayed cerebral ischemia (DCI), or post-hemorrhagic hydrocephalus (HC) may worsen the prognosis. The aim of this study was to evaluate the rate of these complications comparing perimesencephalic (PM) and non-perimesencephalic (NPM) SAH. Monocentric, retrospective analysis of patients diagnosed with NASAH from 01/2010 to 01/2021. Diagnosis was set only if vascular pathologies were excluded in at least one digital subtraction angiography, and NASAH was confirmed by cranial computed tomography (cCT) or lumbar puncture (LP). One hundred patients (62 female) with a mean age of 54.9 years (27–84) were identified. Seventy-three percent had a World Federation of Neurological Surgeons (WFNS) grading scale score I, while 9% were WFNS score IV or V at the time of admission. SAH was diagnosed by cCT in 86%, in 14% by lumbar puncture. Twenty-five percent necessitated short-term CSF diversion by extraventricular drainage or lumbar drainage, whereof 7 suffered from long-term HC treated with ventriculoperitoneal shunting (VPS). One patient without a short-term CSF drainage developed long-term HC. Ten percent developed CV, four of whom received intraarterial spasmolysis. Radiological DCI was diagnosed in 2%; none of these correlated with CV. Despite a mortality of 3% occurring solely in NPM SAH, the analyzed complication rate was comparable in both groups. We observed post-hemorrhagic complications in 35% of cases during the first 3 weeks after bleeding, predominantly in patients with NPM SAH. For this reason, close observation and cranial imaging within this time may be indicated not to overlook these complications.