Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes

• Published in: Diabetes & metabolism Vol. 37; no. 3; pp. 259 - 261
• Main Authors: Abi Khalil, C, Mohammedi, K, Aubert, R, Travert, F, Hadjadj, S, Roussel, R, Fumeron, F, Marre, M
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.06.2011; Masson
• Subjects: Adiponectin; Adiponectin - blood; Adiponectine; Adult; Aged; Biological and medical sciences; Blood Glucose - metabolism; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Diabète de type 1; Diabète de type 2; Endocrine pancreas. Apud cells (diseases); Endocrinology & Metabolism; Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glycaemic control; Glycated Hemoglobin A; Humans; Insulin - therapeutic use; Internal Medicine; Male; Medical sciences; Middle Aged; Protein Isoforms; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Équilibre glycémique; Adiponectine; Diabète de type 1; Diabète de type 2; Type 2 diabetes mellitus; Glycaemic control; Adiponectin; Type 1 diabetes mellitus; Équilibre glycémique; Endocrinopathy; Type 2 diabetes; Immunopathology; Pancreatic hormone; Molecular form; Type 1 diabetes; Autoimmune disease; Metabolic diseases; Adipokine; Insulin
• ISSN: 1262-3636; 1878-1780
• DOI: 10.1016/j.diabet.2010.12.001

Abstract Introduction As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN. Patients and methods A total of 15 T1D and 48 T2D patients with HbA1c greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6 months after insulin treatment. Results While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study. Conclusion Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.