Bioactivities of Steroids and Sesquiterpenes from the Branches and Leaves of Aglaia lawii

Five undescribed steroids and one sesquiterpene, named Aglaians A-F, along with sixteen known analogs, have been isolated from the branches and leaves of . Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 1; p. 39
Main Authors Dong, Jingjing, Liu, Hanfei, Wang, Huan, Lou, Huayong, Pan, Weidong, Li, Jinyu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.12.2023
MDPI
Subjects
Aglaia lawii
antibacterial
cytotoxicity
NMR
Nuclear magnetic resonance
Radiation
sesquiterpenes
steroids
antibacterial
steroids
Aglaia lawii
cytotoxicity
sesquiterpenes
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Summary:Five undescribed steroids and one sesquiterpene, named Aglaians A-F, along with sixteen known analogs, have been isolated from the branches and leaves of . Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The cytotoxic and antibacterial activities of six human tumor cell lines were evaluated (MDA-MB-231, MCF-7, Ln-cap, A549, HeLa, and HepG-2), and four strains of bacteria ( , , , and ). The bioassay results indicated that compounds and exhibited moderate antitumor activity with IC values ranging from 16.72 to 36.14 μM. Furthermore, compounds - possess antibacterial activities against four bacteria with MIC values of 25-100 μM.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29010039