Bioactivities of Steroids and Sesquiterpenes from the Branches and Leaves of Aglaia lawii
Five undescribed steroids and one sesquiterpene, named Aglaians A-F, along with sixteen known analogs, have been isolated from the branches and leaves of . Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and...
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Published in | Molecules (Basel, Switzerland) Vol. 29; no. 1; p. 39 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
20.12.2023
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | Five undescribed steroids and one sesquiterpene, named Aglaians A-F, along with sixteen known analogs, have been isolated from the branches and leaves of
. Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The cytotoxic and antibacterial activities of six human tumor cell lines were evaluated (MDA-MB-231, MCF-7, Ln-cap, A549, HeLa, and HepG-2), and four strains of bacteria (
,
,
, and
). The bioassay results indicated that compounds
and
exhibited moderate antitumor activity with IC
values ranging from 16.72 to 36.14 μM. Furthermore, compounds
-
possess antibacterial activities against four bacteria with MIC values of 25-100 μM. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules29010039 |