Systolic eccentricity index identifies right ventricular dysfunction in pulmonary hypertension

• Published in: International journal of cardiology Vol. 129; no. 3; pp. 424 - 426
• Main Authors: López-Candales, Angel, Rajagopalan, Navin, Kochar, Minisha, Gulyasy, Beth, Edelman, Kathy
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 13.10.2008; Elsevier Science
• Subjects: Adult; Aged; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cardiovascular system; Cohort Studies; Eccentricity index; Echocardiography; Female; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - physiopathology; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Pneumology; Pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Right ventricular area; Right ventricular function; Systole - physiology; Tricuspid annular plane systolic excursion; Ultrasonic investigative techniques; Ventricular Dysfunction, Right - complications; Ventricular Dysfunction, Right - diagnosis; Ventricular Dysfunction, Right - physiopathology; Echocardiography; Eccentricity index; Right ventricular area; Right ventricular function; Pulmonary hypertension; Tricuspid annular plane systolic excursion; Sonography; Respiratory disease; Right ventricle; Cardiovascular disease; Heart ventricle; Index; Right ventricular failure; Area; Heart disease; Cardiology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2007.06.057

Abstract Systolic eccentricity index (sEI) has been shown to correlate with pulmonary hypertension (PH). However, its relative value with regards to other echocardiographic indices of right ventricular (RV) size and function in PH has not been studied. Consequently, several echocardiographic variables were collected from 103 patients (mean age 54 ± 15 years, 46 males) with a mean PASP 62 ± 37 mm Hg (range 24 to 130 mm Hg). Of the studied variables sEI was the only multivariate predictor of PH ( p < 0.0001, 95% CI − 0.924 to − 0.671). This was further confirmed in a subgroup of patients who underwent invasive cardiac hemodynamic assessment showing a similar correlation between invasive hemodynamics and sEI. Based on these results, sEI appears to be an easily obtained variable that should be routinely included in the identification of RV dysfunction in PH patients.