How viral oncogenes make the cell cycle

Oncogenic viruses provide their host cells with additional growth stimuli, thereby extending their proliferative capacity. This implies that viral oncogenes can override growth-suppressive signals, which control cell-cycle progression in untransformed cells. Viral oncoproteins deregulate cell-cycle...

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Bibliographic Details
Published inTrends in Genetics Vol. 12; no. 7; pp. 270 - 275
Main Author Jansen-Dürr, Pidder
Format Book Review Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.07.1996
Elsevier Science
Subjects
adenovirus
Biological and medical sciences
Cell Cycle
Cell Division
Cell Transformation, Viral
Cyclins - biosynthesis
Epstein-Barr virus
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Viral
Genes, cdc
Genetics
human papillomavirus 16
Microbiology
Oncogene Proteins, Viral - physiology
Oncogenic Viruses - growth & development
Oncogenic Viruses - physiology
Signal Transduction
Virology
Virus
Regulation(control)
Cell cycle
V-Onc gene
Regulator gene
Review
Gene expression
Cell transformation
Host virus relation
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Summary:Oncogenic viruses provide their host cells with additional growth stimuli, thereby extending their proliferative capacity. This implies that viral oncogenes can override growth-suppressive signals, which control cell-cycle progression in untransformed cells. Viral oncoproteins deregulate cell-cycle control by interfering with receptor-mediated signal transduction pathways and the function of nuclear cell-cycle regulatory proteins. As a consequence of these regulatory interactions, many viral oncogenes induce the expression of cellular genes required for cell-cycle progression, including genes encoding G1 cyclins. Apparently, different oncogenic viruses target different subsets of these cell-cycle regulatory pathways to transform cells.
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ISSN:0168-9525
DOI:10.1016/0168-9525(96)81455-7