Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019

• Published in: The New England journal of medicine Vol. 386; no. 24; pp. 2283 - 2294
• Main Authors: Loayza Mafayle, Roxana, Morales-Betoulle, Maria E., Romero, Carla, Cossaboom, Caitlin M., Whitmer, Shannon, Alvarez Aguilera, Carlos E., Avila Ardaya, Cinthia, Cruz Zambrana, Mirian, Dávalos Anajia, Andrés, Mendoza Loayza, Nelly, Montaño, Ana-Maria, Morales Alvis, Fernando L., Revollo Guzmán, Jimmy, Sasías Martínez, Sebastián, Alarcón De La Vega, Gricel, Medina Ramírez, Armando, Molina Gutiérrez, Jhemis T., Cornejo Pinto, Alex J., Salas Bacci, Renata, Brignone, Julia, Garcia, Jorge, Añez, Arletta, Mendez-Rico, Jairo, Luz, Kleber, Segales, Ariel, Torrez Cruz, Karen M., Valdivia-Cayoja, Adolfo, Amman, Brian R., Choi, Mary J., Erickson, Bobbie-Rae, Goldsmith, Cynthia, Graziano, James C., Joyce, Allison, Klena, John D., Leach, Austin, Malenfant, Jason H., Nichol, Stuart T., Patel, Ketan, Sealy, Tara, Shoemaker, Trevor, Spiropoulou, Christina F., Todres, Alison, Towner, Jonathan S., Montgomery, Joel M.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 16.06.2022
• Subjects: Abdomen; Animals; Arenaviruses, New World - genetics; Arenaviruses, New World - isolation & purification; Body fluids; Bolivia - epidemiology; Bronchus; Conjunctiva; Cross Infection - transmission; Cross Infection - virology; Dengue fever; Diagnostic tests; Disease Transmission, Infectious; Global Health; Health care; Hemorrhage; Hemorrhagic fever; Hemorrhagic Fever, American - complications; Hemorrhagic Fever, American - genetics; Hemorrhagic Fever, American - transmission; Hemorrhagic Fever, American - virology; Hemorrhagic Fevers, Viral - genetics; Hemorrhagic Fevers, Viral - transmission; Hemorrhagic Fevers, Viral - virology; High-Throughput Nucleotide Sequencing; Hospitalization; Hospitals; Humans; Infectious Disease; Infectious diseases; Laboratories; Lavage; Medical personnel; Neurology; Neurosurgery; Neurosurgery General; Next-generation sequencing; Pain; Pathogens; Patients; Polymerase Chain Reaction; Rats - virology; RNA, Viral - genetics; RNA, Viral - isolation & purification; Rodentia - virology; Rodents; Semen; Surveillance; Tropical diseases; Viral Infections; Viral Zoonoses - transmission; Viral Zoonoses - virology; Viruses; Workers; Bolivia
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2110339

A cluster of cases of hemorrhagic fever was identified in Bolivia. An investigation led to the identification of Chapare virus as the cause. Probable person-to-person transmission was identified.