Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes

The discrimination learning of multiple odors, in which multi-odor can be associated with different responses, is important for responding quickly and accurately to changes in the external environment. However, very few studies have been done on multi-odor discrimination by animal sniffing. Herein,...

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Published inSensors (Basel, Switzerland) Vol. 21; no. 11; p. 3696
Main Authors Oh, Yunkwang, Kwon, Ohseok, Min, Sun-Seek, Shin, Yong-Beom, Oh, Min-Kyu, Kim, Moonil
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 26.05.2021
MDPI
Subjects
2-choice/no-go
animal biosensor
Animals
Behavior
Bias
Diabetes
Discrimination
Food
Humidity
Lung cancer
Monitoring
multi-odor discrimination
Odors
olfactory behavior
Response time
Sensors
Toluene
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Summary:The discrimination learning of multiple odors, in which multi-odor can be associated with different responses, is important for responding quickly and accurately to changes in the external environment. However, very few studies have been done on multi-odor discrimination by animal sniffing. Herein, we report a novel multi-odor discrimination system by detection rats based on the combination of 2-Choice and Go/No-Go (GNG) tasks into a single paradigm, in which the Go response of GNG was replaced by 2-Choice, for detection of toluene and acetone, which are odor indicators of lung cancer and diabetes, respectively. Three of six trained rats reached performance criterion, in 12 consecutive successful tests within a given set or over 12 sets with a success rate of over 90%. Through a total of 1300 tests, the trained animals (N = 3) showed multi-odor sensing performance with 88% accuracy, 87% sensitivity and 90% specificity. In addition, a dependence of behavior response time on odor concentrations under given concentration conditions was observed, suggesting that the system could be used for quantitative measurements. Furthermore, the animals’ multi-odor sensing performance has lasted for 45 days, indicating long-term stability of the learned multi-odor discrimination. These findings demonstrate that multi-odor discrimination can be achieved by rat sniffing, potentially providing insight into the rapid, accurate and cost-effective multi-odor monitoring in the lung cancer and diabetes.
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ISSN:1424-8220
1424-8220
DOI:10.3390/s21113696