The role of ion channels in T cell function and disease

T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of ca...

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Published inFrontiers in immunology Vol. 14; p. 1238171
Main Authors Manolios, Nicholas, Papaemmanouil, John, Adams, David J.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 29.08.2023
Subjects
antigen receptor
calcium signalling
Immunology
ion channels
signal transduction
T cells
therapeutics
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Summary:T lymphocytes (T cells) are an important sub-group of cells in our immune system responsible for cell-mediated adaptive responses and maintaining immune homeostasis. Abnormalities in T cell function, lead the way to the persistence of infection, impaired immunosurveillance, lack of suppression of cancer growth, and autoimmune diseases. Ion channels play a critical role in the regulation of T cell signaling and cellular function and are often overlooked and understudied. Little is known about the ion “channelome” and the interaction of ion channels in immune cells. This review aims to summarize the published data on the impact of ion channels on T cell function and disease. The importance of ion channels in health and disease plus the fact they are easily accessible by virtue of being expressed on the surface of plasma membranes makes them excellent drug targets.
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Reviewed by: Zili Xie, Icahn School of Medicine at Mount Sinai, United States; Cristina Ulivieri, University of Siena, Italy; Henrique Borges da Silva, Mayo Clinic Arizona, United States
ORCID: Nicholas Manolios, orcid.org/0000-0002-6525-7830; David J. Adams, orcid.org/0000-0002-7030-2288
Edited by: Valentyn Oksenych, University of Bergen, Norway
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1238171