Survival of Neural Stem Cells in the Cochlea
Adult rat hippocampus-derived neural stem cells (NSCs) have been reported to have been successfully grafted in several brain regions. To evaluate the possibility of treatment of sensorineural hearing loss using NSCs, survival of NSCs in the cochlea was estimated. NSCs were grafted into newborn rat c...
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Published in | Acta oto-laryngologica Vol. 121; no. 2; pp. 140 - 142 |
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Main Author | |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Stockholm
Informa UK Ltd
2001
Taylor & Francis Taylor and Francis |
Subjects | |
Online Access | Get full text |
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Summary: | Adult rat hippocampus-derived neural stem cells (NSCs) have been reported to have been successfully grafted in several brain regions. To evaluate the possibility of treatment of sensorineural hearing loss using NSCs, survival of NSCs in the cochlea was estimated. NSCs were grafted into newborn rat cochleas. Within 2-4 weeks of grafting to the cochlea, some NSCs survived in the cochlear cavity. Some of them had adopted the morphologies and positions of hair cells. This suggests that NSCs can adapt to the environment of the cochlea and gives hope for treatment of the damaged cochlea and sensorineural hearing loss. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0001-6489 1651-2251 |
DOI: | 10.1080/000164801300043226 |