Simulating realistic membrane shapes

Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, th...

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Published inCurrent opinion in cell biology Vol. 71; pp. 103 - 111
Main Authors Pezeshkian, Weria, Marrink, Siewert J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2021
Subjects
Cell membranes
Membrane curvature
Mesoscale models
Molecular dynamics
Multiscale simulations
Organelle shape
Organelle shape
Mesoscale models
Molecular dynamics
Multiscale simulations
Cell membranes
Membrane curvature
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ISSN0955-0674
1879-0410
1879-0410
DOI10.1016/j.ceb.2021.02.009

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Summary:Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein–lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.
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ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2021.02.009