Cell-culture-derived influenza vaccine production
Adaption of human influenza viruses to grow in the chick embryo alters the haemagglutinin antigen.4,5 Animal studies suggest that the use of vaccine virus antigens grown in mammalian cells could enhance protection after challenge with the human virus.5,6 Also, the immune response might be broader th...
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Published in | The Lancet (British edition) Vol. 377; no. 9767; pp. 698 - 700 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
26.02.2011
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Adaption of human influenza viruses to grow in the chick embryo alters the haemagglutinin antigen.4,5 Animal studies suggest that the use of vaccine virus antigens grown in mammalian cells could enhance protection after challenge with the human virus.5,6 Also, the immune response might be broader than that produced by egg-grown antigens, which allows the possibility of better protection against new variants of prevalent viruses.5 The emergence of new variants has accelerated in recent years, especially for the influenza A H3N2 subtype. [...] the manufacturers should have access to seed viruses that have not been passed in eggs. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 |
ISSN: | 0140-6736 1474-547X |
DOI: | 10.1016/S0140-6736(11)60174-8 |