Cell-culture-derived influenza vaccine production

Adaption of human influenza viruses to grow in the chick embryo alters the haemagglutinin antigen.4,5 Animal studies suggest that the use of vaccine virus antigens grown in mammalian cells could enhance protection after challenge with the human virus.5,6 Also, the immune response might be broader th...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 377; no. 9767; pp. 698 - 700
Main Author Glezen, W Paul
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 26.02.2011
Elsevier Limited
Subjects
Advantages
Animals
Cercopithecus aethiops
Embryos
Hemagglutination Inhibition Tests
Humans
Immune response
Influenza
Influenza A virus - immunology
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Internal Medicine
Multicenter Studies as Topic
Pandemics
Randomized Controlled Trials as Topic
Technology, Pharmaceutical - methods
United States
Vaccines
Vero Cells
Viruses
United States
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Summary:Adaption of human influenza viruses to grow in the chick embryo alters the haemagglutinin antigen.4,5 Animal studies suggest that the use of vaccine virus antigens grown in mammalian cells could enhance protection after challenge with the human virus.5,6 Also, the immune response might be broader than that produced by egg-grown antigens, which allows the possibility of better protection against new variants of prevalent viruses.5 The emergence of new variants has accelerated in recent years, especially for the influenza A H3N2 subtype. [...] the manufacturers should have access to seed viruses that have not been passed in eggs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(11)60174-8