Deep-probe metal-clad waveguide biosensors

Two types of metal-clad waveguide biosensors, so-called dip-type and peak-type, are analyzed and tested. Their performances are benchmarked against the well-known surface-plasmon resonance biosensor, showing improved probe characteristics for adlayer thicknesses above 150–200nm. The dip-type metal-c...

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Published inBiosensors & bioelectronics Vol. 22; no. 7; pp. 1282 - 1288
Main Authors Skivesen, N., Horvath, R., Thinggaard, S., Larsen, N.B., Pedersen, H.C.
Format Journal Article
LanguageEnglish
Published Lausanne Elsevier B.V 15.02.2007
Elsevier Science
Subjects
Biological and medical sciences
Biosensing Techniques - instrumentation
Biosensors
Biotechnology
Cell detection
Fundamental and applied biological sciences. Psychology
Refractometry
Refractometry - instrumentation
Surface Plasmon Resonance - instrumentation
Waveguide sensors
Waveguide sensors
Biosensors
Refractometry
Cell detection
Detector
Biosensor
Metal
Detection
Probe
Waveguide
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Summary:Two types of metal-clad waveguide biosensors, so-called dip-type and peak-type, are analyzed and tested. Their performances are benchmarked against the well-known surface-plasmon resonance biosensor, showing improved probe characteristics for adlayer thicknesses above 150–200nm. The dip-type metal-clad waveguide sensor is shown to be the best all-round alternative to the surface-plasmon resonance biosensor. Both metal-clad waveguides are tested experimentally for cell detection, showing a detection limit of 8–9cells/mm2.
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ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2006.05.025