Biology and pathology of nectins and nectin-like molecules

Immunoglobulin-like nectins contribute to the formation of a variety of cell–cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and prolife...

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Published inCurrent opinion in cell biology Vol. 16; no. 5; pp. 513 - 521
Main Authors Sakisaka, Toshiaki, Takai, Yoshimi
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2004
Subjects
Cell Adhesion Molecules - physiology
Cell Proliferation
Intercellular Junctions - physiology
Models, Biological
Receptors, Virus - physiology
Signal Transduction - physiology
PV
AJ
GEF
Necls
HSV
LMO7
PVR
F-Actin
ADIP
PDGF
TJ
JAM
PSDs
FRG
CAMs
Ig
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Summary:Immunoglobulin-like nectins contribute to the formation of a variety of cell–cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and proliferation, and assist or modify their functions. On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2004.07.007