Novel Synthesis of Dihydroisoxazoles by p -TsOH-Participated 1,3-Dipolar Cycloaddition of Dipolarophiles withα-Nitroketones

This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of -TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient s...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 6; p. 2565
Main Authors Yang, Caiyun, Hu, Sirou, Pan, Xinhui, Yang, Ke, Zhang, Ke, Liu, Qingguang, Xin, Xiaobing, Li, Jie, Wang, Jinhui, Yang, Xiaoda
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.03.2023
MDPI
Subjects
1,3-dipolar cycloaddition
Acids
Alkenes
Alkynes
Communication
Cycloaddition
isoxazolines
p-TsOH
Solvents
α-nitroketones
isoxazolines
α-nitroketones
alkenes
p-TsOH
alkynes
1,3-dipolar cycloaddition
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Summary:This article reports in detail a method for the synthesis of 3-benzoxoxazoline by the reaction of alkenes (alkynes) and a variety of α-nitroketones in the presence of -TsOH. The scope of alkenes is broad, including different alkenes and the alkyne. This reaction provides a convenient and efficient synthetic method of 3-benzoylisoxazolines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28062565