A new near-infrared persistent luminescence nanoparticle as a multifunctional nanoplatform for multimodal imaging and cancer therapy

• Published in: Biomaterials Vol. 152; pp. 15 - 23
• Main Authors: Shi, Junpeng, Sun, Xia, Zheng, Shenghui, Li, Jinlei, Fu, Xiaoyan, Zhang, Hongwu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2018
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cancer therapy; Chromium - chemistry; Drug Carriers; Gadolinium - chemistry; Gallium - chemistry; Humans; Luminescent Agents - chemistry; Magnetic Resonance Imaging - methods; Mice; Multimodal imaging; Multimodal Imaging - methods; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Near-infrared persistent luminescence; Neodymium - chemistry; Optical Imaging - methods; Photoluminescence; Porosity; Silicon Dioxide - chemistry; Multimodal imaging; Near-infrared persistent luminescence; Cancer therapy; Photoluminescence
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2017.10.032

Multifunctional nanoplatforms with multimodal imaging and cancer therapy capabilities have attracted attention in biomedical applications. Near-infrared persistent luminescence nanoparticles (NPLNPs) were considered one of the most promising candidates for constructing multifunctional nanoplatforms due to the absence of in situ excitation and high signal-to-noise ratios (SNRs). Here, we report a novel NPLNP mSiO2@Gd3Ga5O12:Cr3+, Nd3+ (mSiO2@GGO) as multifunctional nanoplatforms for multimodal imaging and cancer therapy. These NPs exhibited a persistent luminescence (745 nm) of more than 3 h in the first near-infrared window (NIR-I) after UV excitation, which can realize high SNRs and long-term in vivo imaging. Moreover, these NPs showed excellent NIR luminescence (1067 nm) in the second near-infrared window (NIR-II) under 808 nm excitation, which is more suitable for deep tissue imaging due to the lower photon scattering and deeper tissue penetration of NIR-II luminescence. Furthermore, the host Gd3Ga5O12 with high Gd3+ concentration showed a high r1 value (10.70 mM−1 s−1) and was suitable for T1 MR imaging. The mesoporous silica nanoparticles (mSiO2) served as a framework to control the mSiO2@GGO particle morphology and provide low toxicity and drug loading capacity for cancer therapy. [Display omitted]