Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies

• Published in: Hypertension in pregnancy Vol. 39; no. 2; pp. 89 - 94
• Main Authors: Madazlı, Riza, Kaymak, Didem, Alpay, Verda, Erenel, Hakan, Dincer, M. Tamer, Seyahi, Nurhan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.04.2020; Taylor & Francis Group
• Subjects: Adult; Female; Fetal Growth Retardation - epidemiology; Fetal Growth Retardation - physiopathology; glomerular filtration rate; Glomerular Filtration Rate - physiology; Humans; Incidence; Kidney - physiopathology; Kidney transplant; Kidney Transplantation; obstetric outcomes; Pre-Eclampsia - epidemiology; Pre-Eclampsia - physiopathology; Pregnancy; Pregnancy Outcome; Prognosis; Retrospective Studies; Transplant Recipients; Kidney transplant; obstetric outcomes; glomerular filtration rate; pregnancy
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641955.2020.1727498

To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation. We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients. The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = −0.546, p = .0.001) and composite adverse obstetric outcome (r = −0.415, p = .0.018). The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.