Burden of smoking on quality of life in patients with chronic obstructive pulmonary disease

• Published in: Expert review of pharmacoeconomics & outcomes research Vol. 13; no. 6; pp. 853 - 860
• Main Authors: Galaznik, Aaron, Chapnick, Jonathan, Vietri, Jeffrey, Tripathi, Shivani, Zou, Kelly H, Makinson, Geoffrey
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2013; Taylor & Francis
• Subjects: Absenteeism; activity impairment; Adult; Age; Aged; Alcohol use; Asthma; Binomial distribution; Bronchitis; Bronchitis, Chronic - economics; Bronchitis, Chronic - physiopathology; Chronic obstructive pulmonary disease; COPD; Cost of Illness; Demographics; Efficiency; Emphysema; Emphysema - economics; Emphysema - physiopathology; Exercise; Family income; Female; Gender; Generalized linear models; Health Care Costs - statistics & numerical data; Health insurance; Health Surveys; Hispanic people; Households; Humans; Male; Marital status; Middle Aged; Productivity; Pulmonary Disease, Chronic Obstructive - economics; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of Life; Questionnaires; Smoking; Smoking - adverse effects; Smoking - economics; Smoking - epidemiology; Surveys and Questionnaires; United States - epidemiology; Variables; Variance analysis; work productivity; United States
• ISSN: 1473-7167; 1744-8379
• DOI: 10.1586/14737167.2013.842128

The objective of this study was to assess the impact of smoking on health-related quality of life, Work Productivity and Activity Impairment (WPAI) in chronic obstructive pulmonary disease (COPD) patients. Respondents of the 2009/2010 US National Health and Wellness Survey (NHWS), aged ≥40 years, with COPD, chronic bronchitis or emphysema, were included in the study. Current and former (had not smoked for ≥11 years) smokers were compared. Physical component summary (PCS) and mental component summary (MCS) scores from the Short Form-12 version 2 (SF-12v2), health utilities (SF-6D) and WPAI were evaluated. Differences between current (n = 1685) and former (n = 1932) smokers were revealed: MCS (44.80, 46.73; p < 0.01); PCS (35.12, 35.79; p < 0.1); SF-6D (0.63, 0.65; p < 0.05). WPAI: presenteeism (23%, 18%; p < 0.05); work impairment (25%, 21%; p < 0.05); activity impairment (52%, 49%; p < 0.01). In conclusion, COPD patients who smoke have poorer health-related quality of life, impaired productivity and higher healthcare costs than former smokers.