Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge

• Published in: Oral oncology Vol. 72; pp. 7 - 16
• Main Authors: Ramos-García, Pablo, Ruiz-Ávila, Isabel, Gil-Montoya, José Antonio, Ayén, Ángela, González-Ruiz, Lucía, Navarro-Triviño, Francisco José, González-Moles, Miguel Ángel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2017
• Subjects: 11q13; Carcinogenesis; Carcinoma, Squamous Cell - genetics; Chromosomes, Human, Pair 11; Gene Amplification; Humans; Mouth Neoplasms - genetics; Oral cancer; Oral cancer; 11q13; Carcinogenesis
• ISSN: 1368-8375; 1879-0593
• DOI: 10.1016/j.oraloncology.2017.04.016

•11q13 amplification is a key event in oral carcinogenesis.•We examine the 11q13 amplicon and its amplicon cores and drivers in OSCC.•We review the oncogenic implications of oncogenes in the 11q13 amplicon.•We analyze the therapeutic targeting of chromosome band 11q13 in HNSCC and OSCC.•We discuss future research lines. An important event in oral carcinogenesis is the amplification of chromosomal band 11q13, in which numerous oncogenes and some tumor-suppressor genes are localized and frequently co-amplified during the malignant transformation of oral epithelium. The objectives of this study were to review published data on the involvement of 11q13 amplification in oral cancer, to provide an update on novel concepts and terminology related to gene amplification, and to explore the composition of the 11q13 amplicon in OSCC, including its most relevant amplicon cores and potential drivers. We report on the critical oncogenes and tumor-suppressor genes in 11q13 that may play a major role in oral cancer, focusing on their functions, on the characteristics acquired by their amplification, and on their clinicopathological implications. Finally, we discuss the possible usefulness of the 11q13 region as a therapeutic target in oral cancer.