Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)

Abstract Rationale The purposes of this study were to 1) conduct a review of neuropsychological (NP) outcomes after epilepsy surgery for DNET and 2) present pre/post-surgical NP results from a series of children with DNET. Methods First, a systematic literature review was conducted with specific inc...

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Bibliographic Details
Published inEpilepsy & behavior Vol. 23; no. 4; pp. 481 - 486
Main Authors Fay-McClymont, Taryn B, Hrabok, Marianne, Sherman, Elisabeth M.S, Hader, Walter J, Connolly, Mary B, Akdag, Sare, Mohamed, Ismail S, Wiebe, Samuel
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2012
Subjects
Adolescent
Child
Child, Preschool
Children
Cognition Disorders - etiology
Cognition Disorders - surgery
DNET
Dysembryoplastic neuroepithelial tumor
Epilepsy
Epilepsy - complications
Epilepsy - surgery
Female
Hospitals
Humans
Intelligence
Literature reviews
Male
Neoplasms, Neuroepithelial - complications
Neoplasms, Neuroepithelial - surgery
Neurology
Neuropsychological functioning
Neuropsychological Tests
Pediatrics
Retrospective Studies
Seizures
Surgery
Teratoma - complications
Teratoma - surgery
Treatment Outcome
Tumors
Neuropsychological functioning
Intelligence
Dysembryoplastic neuroepithelial tumor
Epilepsy
Surgery
IQ
DNET
Children
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Summary:Abstract Rationale The purposes of this study were to 1) conduct a review of neuropsychological (NP) outcomes after epilepsy surgery for DNET and 2) present pre/post-surgical NP results from a series of children with DNET. Methods First, a systematic literature review was conducted with specific inclusion criteria. Second, a review of DNET surgical patients seen at two tertiary-care hospitals using reliable change methods of NP functioning was conducted. Results Of 300 citations retrieved, 7 studies met criteria. Studies reported low average to average pre-surgical IQ. Engel Class I outcome was approximately 85%. Case Series : Thirteen children completed pre/post-surgical NP assessments. Pre-surgically, children demonstrated low average to average functioning. Post-surgically, few patients showed reliable change. One-third of children demonstrated psychological improvement. Conclusions NP outcome following DNET has not been well-described. Children with DNET demonstrate low average to average NP functioning pre-surgically, good seizure outcome, and stable NP functioning post-surgically.
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ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2011.12.011