Performance and Acceptability of a New Dexpanthenol-Containing Hand Cream in Subjects with Sensitive and Very Dry Skin: A Randomized Controlled Study

A new dexpanthenol-containing hand cream (ND-HC) was developed for people with dry, sensitive, and/or environmentally stressed hands. To explore the performance and acceptability of ND-HC, we conducted a randomized, intraindividual comparison study in 40 healthy adult subjects with sensitive and ver...

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Bibliographic Details
Published inCosmetics (Basel) Vol. 9; no. 3; p. 44
Main Authors Stettler, Hans, de Salvo, Raffaella, Brandt, Marianne, Effertz, Ann-Kathrin, Laing, Sabrina, Trapp, Sonja
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 19.04.2022
Subjects
Capacitance
Care and treatment
Chemical properties
Cosmetics
dexpanthenol
dry skin
hand cream
Hands
Hydration
moisturization
Pantothenic acid
Pharmaceutical research
Questionnaires
Skin
skin barrier
Skin care products
Stratum corneum
study
United States
Switzerland
Germany
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Summary:A new dexpanthenol-containing hand cream (ND-HC) was developed for people with dry, sensitive, and/or environmentally stressed hands. To explore the performance and acceptability of ND-HC, we conducted a randomized, intraindividual comparison study in 40 healthy adult subjects with sensitive and very dry skin on the hands. Instrumental measurements determined the effects on stratum corneum (SC) hydration and transepidermal water loss (TEWL) after single and/or 4 weeks’ use of ND-HC. Single and continued at least four times daily applications of ND-HC to very dry skin of the hand for 4 weeks triggered significant increases in SC hydration. On day 29, the mean change in skin capacitance from baseline was significantly greater when ND-HC was applied to the test area compared with the untreated area on the contralateral hand (12.41 vs. 4.46 a.u.; p < 0.001). Upon use of ND-HC over 4 weeks, mean TEWL decreased significantly (bilateral difference: −1.8 vs. 1.0 g/m2/h; p = 0.003), indicating an improvement in SC barrier function. A reduction in dry hand symptoms was observed over the study course. ND-HC was well tolerated and achieved a high level of acceptance and satisfaction. Our findings suggest that ND-HC complies with the required features of a state-of-the-art hand cream.
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ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics9030044