Characterization of microvascular tortuosity in retinal vein occlusion utilizing optical coherence tomography angiography

• Published in: Scientific reports Vol. 10; no. 1; p. 17788
• Main Authors: Lee, Hyungwoo, Kim, Myung Ae, Kim, Hyung Chan, Chung, Hyewon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2020
• Subjects: 692/308/53/2422; 692/699/3161; Aged; Angiography; Eye - pathology; Female; Humanities and Social Sciences; Humans; Male; Microvessels - anatomy & histology; Microvessels - diagnostic imaging; Middle Aged; multidisciplinary; Neovascularization, Pathologic; Organ Size; Prognosis; Retinal Vein - anatomy & histology; Retinal Vein - pathology; Retinal Vein Occlusion - diagnosis; Science; Science (multidisciplinary); Tomography, Optical Coherence - methods; Visual Acuity
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-74871-7

We investigated the characteristics of microvessel tortuosity in branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and their associations with visual outcomes using optical coherence tomography angiography (OCTA). Thirty-four BRVO and 21 CRVO patients and 31 healthy subjects were included. From OCTA, the branch number (BN), mean branch length (BL), mean Euclidean length (EL), vessel density (VD) and vessel tortuosity (VT) were quantified. In BRVO eyes, compared with that in the controls, the affected area of the deep capillary plexus (DCP) showed a decreased BN and VD, an increased BL, and unchanged VT. The nonaffected area of the DCP showed decreases in BN, VD and VT. The affected area of the superficial capillary plexus (SCP) showed higher VT. In CRVO eyes, the DCP showed a lower BN, VD and VT, while the SCP showed a lower BN and greater BL and EL. Improved visual acuity (VA) after 1 year in BRVO eyes was associated with decreases in BN, BL, VD and VT in the affected area in the DCP and lower VT in the nonaffected area of the SCP; in CRVO eyes, improved VA was associated with a higher BL and EL in the DCP. VT, BL, and EL may be new microvascular markers associated with changes in VA in BRVO and CRVO.