MicroRNA-140 and the silencing of osteoarthritis

MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Mo...

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Bibliographic Details
Published inGenes & development Vol. 24; no. 11; pp. 1075 - 1080
Main Authors Araldi, Elisa, Schipani, Ernestina
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.06.2010
Subjects
ADAM Proteins - metabolism
ADAMTS5 Protein
Animals
Cartilage - growth & development
Cartilage - metabolism
Gene Expression Regulation, Developmental
Gene Silencing
Growth Plate - growth & development
Humans
Mice
MicroRNAs - genetics
MicroRNAs - metabolism
Osteoarthritis - metabolism
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Summary:MicroRNAs (miRNAs) have emerged as important modulators in development, tissue homeostasis, and diseases. In this issue of Genes & Development, Miyaki and colleagues (pp. 1173-1185) report that miR-140 is involved in the pathogenesis of osteoarthritis by regulating, at least in part, ADAMTS5. Moreover, mice lacking miR-140 are dwarf as a consequence of impaired chondrocyte proliferation. This study is the first in vivo demonstration that miR-140 has a critical and nonredundant role in cartilage development and homeostasis.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1939310