Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome

• Published in: British journal of nutrition Vol. 110; no. 10; pp. 1885 - 1894
• Main Authors: Simão, Tathiana Name Colado, Lozovoy, Marcell Alysson Batisti, Simão, Andréa Name Colado, Oliveira, Sayonara Rangel, Venturini, Danielle, Morimoto, Helena Kaminami, Miglioranza, Lúcia Helena Silva, Dichi, Isaias
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.11.2013
• Subjects: Adiponectin - blood; Adult; Amino acids; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Beverages; Biological and medical sciences; Cardiovascular Diseases - etiology; Energy Intake; Feeding. Feeding behavior; Female; Folic Acid - blood; Fruit; Fruit juices; Fundamental and applied biological sciences. Psychology; Homocysteine - blood; Human and Clinical Nutrition; Humans; Lipid Peroxidation - drug effects; Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - drug therapy; Middle Aged; Miscellaneous; Nutrition research; Other metabolic disorders; Oxidative Stress; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; Protein Carbonylation - drug effects; Vaccinium macrocarpon; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Cranberry juice; Metabolic syndrome; Homocysteine; Folic acid; Adiponectin; Endocrinopathy; Human; Oxidative stress; Nutrition; Metabolic diseases; Cardiovascular disease; Adipokine; Cranberries; Micronutrient; Vaccinium; Energy; Homocystein; Dicotyledones; Angiospermae; Spermatophyta; Ericaceae
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114513001207

The metabolic syndrome (MetS) comprises pathological conditions that include insulin resistance, arterial hypertension, visceral adiposity and dyslipidaemia, which favour the development of CVD. Some reports have shown that cranberry ingestion reduces cardiovascular risk factors. However, few studies have evaluated the effect of this fruit in subjects with the MetS. The objective of the present study was to assess the effect of reduced-energy cranberry juice consumption on metabolic and inflammatory biomarkers in patients with the MetS, and to verify the effects of cranberry juice concomitantly on homocysteine and adiponectin levels in patients with the MetS. For this purpose, fifty-six individuals with the MetS were selected and divided into two groups: control group (n 36) and cranberry-treated group (n 20). After consuming reduced-energy cranberry juice (0·7 litres/d) containing 0·4 mg folic acid for 60 d, the cranberry-treated group showed an increase in adiponectin (P= 0·010) and folic acid (P= 0·033) and a decrease in homocysteine (P< 0·001) in relation to baseline values and also in comparison with the controls (P< 0·05). There was no significant change in the pro-inflammatory cytokines TNF-α, IL-1 and IL-6. In relation to oxidative stress measurements, decreased (P< 0·05) lipoperoxidation and protein oxidation levels assessed by advanced oxidation protein products were found in the cranberry-treated group when compared with the control group. In conclusion, the consumption of cranberry juice for 60 d was able to improve some cardiovascular risk factors. The present data reinforce the importance of the inverse association between homocysteine and adiponectin and the need for more specifically designed studies on MetS patients.