Oxytocin, Vasopressin, and Estrogen-Stimulated Neurophysin: Daily Patterns of Concentration in Cerebrospinal Fluid

• Published in: Science (American Association for the Advancement of Science) Vol. 216; no. 4553; pp. 1416 - 1418
• Main Authors: Perlow, M. J., Reppert, S. M., Artman, H. A., Fisher, D. A., Seif, S. M., Robinson, A. G.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 25.06.1982; American Association for the Advancement of Science
• Subjects: Animals; Arginine Vasopressin - blood; Arginine Vasopressin - cerebrospinal fluid; Blood; Blood plasma; Carrier proteins; Cerebrospinal fluid; Circadian Rhythm; Endocrinology; Estradiol - pharmacology; Hormone research; Kimchi; Macaca mulatta; Male; Male animals; Neurons; Neurons, Efferent - metabolism; Neurophysins; Neurophysins - cerebrospinal fluid; Oxytocin; Oxytocin - blood; Oxytocin - cerebrospinal fluid; Phosphates
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.7201163

The concentrations of oxytocin, arginine vasopressin, and estrogenstimulated neurophysin in cerebrospinal fluid of monkeys showed a daily fluctuation with high concentrations occurring during the light period. The patterns of oxytocin and estrogen-stimulated neurophysin in the cerebrospinal fluid were not observed in the plasma nor were they altered after the administration of a dose of estradiol that increased concentrations of estrogen-stimulated neurophysin in plasma. The disassociation between these cerebrospinal fluid and plasma patterns and values suggests that the secretory activity of neurons that release estrogen-stimulated neurophysin and oxytocin into the cerebrospinal fluid is controlled by mechanisms different from those that control their release into the plasma.