Cytoskeletal control of the secretory immune synapse

The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the im...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 71; pp. 87 - 94
Main Authors Douanne, Tiphaine, Griffiths, Gillian M.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2021
Subjects
Actin
Centrosome
Immune synapse
Immunodeficiencies
Secretion
Immune synapse
Actin
Secretion
Immunodeficiencies
Centrosome
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ISSN0955-0674
1879-0410
1879-0410
DOI10.1016/j.ceb.2021.02.008

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Summary:The immune synapse is a very important but often transient site for secretion between immune cells. How secretion is controlled in a coordinated fashion at the synapse is a subject of much investigation. Two key mechanisms are the polarisation of the centrosome and rapid actin dynamics across the immune synapses that form between interacting immune cells. In recent years it has become clear that different immune cells utilise a diversity of immune synapses that modify these mechanisms in order to optimise specialised modes of secretion. Here we describe some of the latest research, focusing on regulation by centrosomal and actin dynamics in a variety of immune cells.
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ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2021.02.008