Dendritic cells in liver transplantation immune response

Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they are considered one of the key regulatory factors in the liver immune system. There is currently much interest in modulating DC function to improve transplant immune response. In liver transplantation, DCs participate i...

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Published inFrontiers in cell and developmental biology Vol. 11; p. 1277743
Main Authors Du, Xiaodong, Li, Mingqian, Huan, Chen, Lv, Guoyue
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 13.10.2023
Subjects
Cell and Developmental Biology
DC based treatment
dendritic cells
immune rejection
immune tolerance
liver transplantation
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Summary:Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they are considered one of the key regulatory factors in the liver immune system. There is currently much interest in modulating DC function to improve transplant immune response. In liver transplantation, DCs participate in both the promotion and inhibition of the alloreponse by adopting different phenotypes and function. Thus, in this review, we discussed the origin, maturation, migration and pathological effects of several DC subsets, including the conventional DC (cDC), plasmacytoid DC (pDC) and monocyte-derived DC (Mo-DC) in liver transplantation, and we summarized the roles of these DC subsets in liver transplant rejection and tolerance. In addition, we also outlined the latest progress in DC-based related treatment regimens. Overall, our discussion provides a beneficial resource for better understanding the biology of DCs and their manipulation to improve the immune adaptability of patients in transplant status.
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Reviewed by: Scott Philip Davies, University of Birmingham, United Kingdom
Ahmed Uosef, Houston Methodist Hospital, United States
These authors have contributed equally to this work
Edited by: Antonios Chatzigeorgiou, National and Kapodistrian University of Athens, Greece
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2023.1277743