PHARMACOKINETICS OF ATRACURIUM IN ACUTE HEPATIC FAILURE (WITH ACUTE RENAL FAILURE)

The pharmacokinetic profile of atracurium was examined in six patients with acute hepatic and renal failure and compared with that in six normal patients after an i.v. bolus (mean dose 0.7 mg kg−1). The plasma concentrations were measured by high pressure liquid chromatography and the data fitted to...

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 55; no. 12; pp. 1169 - 1172
Main Authors WARD, S., NEILL, E.A.M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.1983
Oxford University Press
Subjects
Acute Kidney Injury - blood
Acute Kidney Injury - complications
Anesthetics. Neuromuscular blocking agents
Atracurium
Biological and medical sciences
Half-Life
Hepatic Encephalopathy - blood
Hepatic Encephalopathy - complications
Humans
Isoquinolines - blood
Kinetics
Medical sciences
Neuromuscular Blocking Agents - blood
Neuropharmacology
Pharmacology. Drug treatments
Pharmacokinetics
Liver failure
Acute
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Summary:The pharmacokinetic profile of atracurium was examined in six patients with acute hepatic and renal failure and compared with that in six normal patients after an i.v. bolus (mean dose 0.7 mg kg−1). The plasma concentrations were measured by high pressure liquid chromatography and the data fitted to a two-compartment pharmacokinetic model. The results from the two groups were not significantly different, giving a mean plasma elimination half-life of 22 min in patients with severe hepatic and renal failure and a mean of 21 min in the normal group.
Bibliography:ark:/67375/HXZ-Z2BWB62G-F
ArticleID:55.12.1169
istex:AC953042145F62B563EFAC7D417BED3770C03145
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/55.12.1169