Mutagenicity testing of agent orange components and related chemicals

Components of the herbicide Agent Orange--2,4-dichlorophenoxyacetic acid (2,4,-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and their esters, and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)--and related chemicals were tested for mutagenicity using Salmonella typhimurium strains...

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Bibliographic Details
Published inToxicology and applied pharmacology Vol. 75; no. 1; p. 137
Main Authors Mortelmans, K, Haworth, S, Speck, W, Zeiger, E
Format Journal Article
LanguageEnglish
Published United States 01.01.1984
Subjects
2,4,5-Trichlorophenoxyacetic Acid - toxicity
2,4-Dichlorophenoxyacetic Acid - toxicity
Agent Orange
Dioxins - toxicity
Mutagenicity Tests
Mutagens - toxicity
Polychlorinated Dibenzodioxins - toxicity
Salmonella typhimurium - drug effects
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Summary:Components of the herbicide Agent Orange--2,4-dichlorophenoxyacetic acid (2,4,-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and their esters, and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)--and related chemicals were tested for mutagenicity using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537. No mutagenic activity was observed for any of the chemicals tested.
ISSN:0041-008X
DOI:10.1016/0041-008x(84)90084-x