Prognostic factors in nursing and healthcare-associated pneumonia

• Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 26; no. 6; pp. 563 - 569
• Main Authors: Yamagata, Akira, Ito, Akihiro, Nakanishi, Yosuke, Ishida, Tadashi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2020
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Aspiration pneumonia; Comorbidity; Drug resistance; Drug Resistance, Bacterial; Female; Healthcare-Associated Pneumonia - diagnosis; Healthcare-Associated Pneumonia - microbiology; Healthcare-Associated Pneumonia - mortality; Hospital Mortality; Humans; Japan; Klebsiella pneumoniae - pathogenicity; Male; Mortality; Nursing and healthcare-associated pneumonia; Pneumonia, Bacterial - diagnosis; Pneumonia, Bacterial - microbiology; Pneumonia, Bacterial - mortality; Prognosis; Prospective Studies; Risk Factors; Staphylococcus aureus - pathogenicity; Japan; Prognosis; Drug resistance; Nursing and healthcare-associated pneumonia; Aspiration pneumonia; Mortality
• ISSN: 1341-321X; 1437-7780
• DOI: 10.1016/j.jiac.2020.01.009

Nursing and healthcare-associated pneumonia (NHCAP) is a category of healthcare-associated pneumonia modified for the healthcare system in Japan. To date, only a few studies have examined the prognostic factors of NHCAP in a prospective cohort. This study aimed to investigate the prognostic factors related to 30-day mortality in patients with NHCAP by analyzing prospective data. We analyzed patients hospitalized for NHCAP who were enrolled between October 2010 and February 2017. Age, sex, comorbidities, vital signs and laboratory findings were used as prognostic variables. The primary outcome was 30-day mortality. Of 817 NHCAP patients identified, the mean age was 78.0 ± 11.1 years, 580 (71.0%) were men and 30-day mortality was 13.1% (107/817). On multivariate analysis, male sex (odds ratio [OR]: 2.07, 95% confidence interval [CI]: 1.18–3.63), malignancy (OR: 2.35, 95%CI: 1.38–4.01), performance status (PS) (OR: 1.55, 95%CI: 1.23–1.96), body temperature (OR: 0.77, 95%CI: 0.61–0.97), heart rate (OR: 1.02, 95%CI: 1.01–1.03), respiratory rate (OR: 1.04, 95%CI: 1.01–1.08), serum albumin (Alb) (OR: 0.45, 95%CI: 0.30–0.66) and blood urea nitrogen (BUN) (OR: 1.02, 95%CI: 1.01–1.03) were significantly related to 30-day mortality. On the other hand, the risk factors for involvement by drug-resistant pathogens predicted a better prognosis (OR: 0.39, 95%CI: 0.19–0.82). Male sex, malignancy, poor PS, hypothermia, tachycardia, tachypnea, low serum Alb and high BUN are worse prognostic factors. Thus, the risk of drug-resistant pathogens is not necessarily related to poor prognosis.