Low-dose postoperative aprotinin reduces mediastinal drainage and blood product use in patients undergoing primary coronary artery bypass grafting who are taking aspirin: A prospective, randomized, double-blind, placebo-controlled trial

• Published in: Journal of thoracic and cardiovascular surgery Vol. 122; no. 3; pp. 457 - 463
• Main Authors: Alvarez, John M., Jackson, Lee R., Chatwin, Clare, Smolich, Joseph J.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.09.2001; AATS/WTSA; Elsevier
• Subjects: Aged; Aprotinin - therapeutic use; Aspirin - adverse effects; Biological and medical sciences; Blood Component Transfusion - statistics & numerical data; Combined Modality Therapy; Coronary Artery Bypass - adverse effects; Coronary Disease - drug therapy; Coronary Disease - surgery; Double-Blind Method; Drainage; Female; Hemoglobins - analysis; Hemostatics - therapeutic use; Humans; Infusions, Intravenous; Male; Mediastinum; Medical sciences; Middle Aged; Platelet Aggregation Inhibitors - adverse effects; Postoperative Care - methods; Postoperative Hemorrhage - blood; Postoperative Hemorrhage - etiology; Postoperative Hemorrhage - prevention & control; Prospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Time Factors; Blood product; Human; Postoperative; Mediastinum; Toxicity; Low dose; Treatment efficiency; Use; Acetylsalicylic acid; Drainage; Prevention; Chemotherapy; Treatment; Aortocoronary; Bypass; Surgery; Blood loss; Graft; Aprotinin; Salicylates
• ISSN: 0022-5223; 1097-685X
• DOI: 10.1067/mtc.2001.115701

Background: Although low-dose aprotinin administered after cardiopulmonary bypass has been reported to reduce mediastinal blood loss and blood product requirements in patients not taking aspirin, it is unknown whether low-dose postoperative aprotinin has any beneficial effects in patients undergoing coronary artery bypass operations who are at high risk of excessive postoperative bleeding and increased transfusion requirements because of aspirin use until just before the operation. Methods: Fifty-five patients undergoing primary coronary artery operations with cardiopulmonary bypass who continued taking aspirin (150 mg/d) until the day before the operation were enrolled in a prospective, randomized, double-blind trial to receive a single dose of either placebo (n = 29) or 2 × 10 6 kallikrein inhibiting units of aprotinin (n = 26) at the time of sternal skin closure. Results: Patients in the aprotinin group had a lower rate (28 ± 18 vs 43 ± 21 mL/h [mean ± standard deviation], P < .005) and total volume of mediastinal drainage (955 ± 615 vs 1570 ± 955 mL, P < .007), as well as a shorter duration of mediastinal drain tube insertion (24.4 ± 13.8 vs 31.3 ± 16.5 hours, P < .05). In addition, a smaller proportion of patients receiving aprotinin required a blood product (31% vs 62%, P = .03), resulting in a reduction in the use of packed cells by 47% ( P = .05), platelets by 77% ( P = .01), fresh frozen plasma by 88% ( P = .03), and total blood products by 68% ( P = .01) in this group. Conclusions: These results suggest that postoperative administration of low-dose aprotinin in patients taking aspirin until just before primary coronary artery operations with cardiopulmonary bypass not only reduces the rate and total amount of postoperative mediastinal blood loss but also lowers postoperative blood product use.