Antiviral effects of interferon-stimulated genes in bats

The interferon pathway is the first line of defense in viral infection in all mammals, and its induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and also humans, the antiviral function of ISGs has been extensively studied. As an important viral reservoir in nature,...

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Bibliographic Details
Published inFrontiers in cellular and infection microbiology Vol. 13; p. 1224532
Main Authors Zhang, Dan, Irving, Aaron T.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 18.08.2023
Subjects
antiviral
bat
Cellular and Infection Microbiology
IFN
interferon pathway
ISGs
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Summary:The interferon pathway is the first line of defense in viral infection in all mammals, and its induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and also humans, the antiviral function of ISGs has been extensively studied. As an important viral reservoir in nature, bats can coexist with a variety of pathogenic viruses without overt signs of disease, yet only limited data are available for the role of ISGs in bats. There are multiple species of bats and work has begun deciphering the differences and similarities between ISG function of human/mouse and different bat species. This review summarizes the current knowledge of conserved and bat-specific-ISGs and their known antiviral effector functions.
Bibliography:ObjectType-Article-2
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Reviewed by: Bertrand Pain, INRAE Clermont-Auvergne-Rhône-Alpes, France
Edited by: Efstathios Giotis, University of Essex, United Kingdom
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2023.1224532