Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

• Published in: Diabetes (New York, N.Y.) Vol. 64; no. 7; pp. 2477 - 2488
• Main Authors: Eljaafari, Assia, Robert, Maud, Chehimi, Marwa, Chanon, Stephanie, Durand, Christine, Vial, Guillaume, Bendridi, Nadia, Madec, Anne-Marie, Disse, Emmanuel, Laville, Martine, Rieusset, Jennifer, Lefai, Etienne, Vidal, Hubert, Pirola, Luciano
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.07.2015
• Subjects: Adipocytes - physiology; Adipose Tissue - cytology; Animals; Binding sites; Cell Communication; Cells; Inflammation - etiology; Insulin - pharmacology; Insulin resistance; Interleukin-17 - biosynthesis; Interleukin-17 - genetics; Interleukin-1beta - secretion; Interleukin-6 - secretion; Life Sciences; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Monocytes - physiology; Obesity; Obesity - complications; Obesity - immunology; Phosphatidylinositol 3-Kinases - physiology; Phosphorylation; STAT Transcription Factors - physiology; Stem Cells - physiology; Th1 Cells - immunology; Th17 Cells - immunology; Stem Cells/physiology; Obese; Interleukin-17/biosynthesis/genetics; Cell Communication; Male; Interleukin-1beta/secretion; Phosphatidylinositol 3-Kinases/physiology; Inbred C57BL; Obesity/complications/immunology; STAT Transcription Factors/physiology; Insulin/pharmacology; Monocytes/physiology; Animals; Inflammation/etiology; Interleukin-6/secretion; Adipose Tissue/cytology; Th17 Cells/immunology; Mice; Th1 Cells/immunology; Adipocytes/physiology

Obesity, through low-grade inflammation, can drive insulin resistance and type 2 diabetes. While infiltration of adipose tissue (AT) with mononuclear cells (MNCs) is well established in obesity, the functional consequences of these interactions are less understood. Herein, we cocultured human adipos...