Auditory evoked potentials remain abnormal after CPAP treatment in patients with severe obstructive sleep apnoea

• Published in: Clinical neurophysiology Vol. 123; no. 2; pp. 310 - 317
• Main Authors: Vakulin, Andrew, Catcheside, Peter G, Baulk, Stuart D, Antic, Nick A, van den Heuvel, Cameron J, Banks, Siobhan, McEvoy, R. Doug
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ireland Ltd 01.02.2012; Elsevier
• Subjects: Acoustic Stimulation - methods; Biological and medical sciences; Continuous Positive Airway Pressure - methods; CPAP; Electrodiagnosis. Electric activity recording; ERP; Evoked Potentials, Auditory - physiology; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Neurology; Obstructive sleep apnoea; Severity of Illness Index; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - therapy; Sleep. Vigilance; Treatment Outcome; Vertebrates: nervous system and sense organs; ERP; Obstructive sleep apnoea; CPAP; Human; Evaluation; Nervous system diseases; Sleep apnea syndrome; Respiratory disease; Interaction; Electrophysiology; Electrodiagnosis; Improvement; Treatment; Positive pressure; Auditory evoked potential; Risk factor; Sensory disorder; Safety; Performance; Event evoked potential
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2011.07.004

Highlights ► This study shows that patients with severe OSA show abnormal auditory ERP responses compared to healthy controls. ► There was only partial improvement in P3 latency following three months of CPAP. ► The findings suggest that cortical function abnormalities persist in these patients despite treatment.